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Safety and efficacy of peptide bioregulators
We continue the series of articles in which specialists from the scientific department of Peptides, the exclusive representative of the St. Petersburg Institute of Bioregulation and Gerontology, answer the frequently asked questions of our readers. The purpose of these information materials is to cover the most relevant topics related to peptide bioregulators and their applications in a competent and accessible way.
We are often asked questions about the safety and efficacy of peptide bioregulators. Irina Yuryevna Saburova, the company's medical consultant, geneticist, PhD, will answer them.
Why do you produce oral peptide bioregulators, since peptides are degraded into amino acids in the gastrointestinal tract?
Yes, indeed, even 10 years ago, doctors were sure of this. However, today, a mechanism has been discovered by which intestinal cells can capture the contents of the intestinal lumen of a larger size (5–7 amino acid residues) and transfer them unchanged to the capillaries. This mechanism allows peptide fragments to reach first the liver without being destroyed, and then the tissues and cells of target organs.
Since peptides stimulate the multiplication (proliferation) of cells, can they provoke cancer in the stimulated organ or in other organs and tissues?
No, they can't. First, peptide bioregulators have a tissue-specific effect and can only affect target cells of those tissues from which they were extracted. Thus, the nervous tissue peptide affects only nerve cells, the liver peptide affects only liver hepatocytes, and so on. Scientific research proved these results. You can read about them both in the articles and monographs of the Institute of Bioregulation and Gerontology, and in the manuals on peptide bioregulation published by our company.
Secondly, peptide bioregulators cause not only proliferation, but also differentiation of cells of the corresponding tissue, that is, in this sense, they have just an oncoprotective effect. Peptides restore the normal protein-synthetic function in both young and already mature cells, preventing their degeneration into cancer cells.
Thirdly, our two flagship peptide bioregulators - Endoluten and Vladonix, containing pineal gland peptide and thymus peptide, respectively, have a scientifically proven anti-oncological effect. Their use reduced the appearance of both spontaneous and induced tumors in the population of experimental animals by 1.5–2 times!
These peptides have also been successfully used with cancer patients. When using them, leukopenia and toxic manifestations caused by radiation and chemotherapy treatment decreased, the general well-being of patients improved, the oncological process stabilized, and the risk of metastasis decreased.
Do peptide bioregulators have any side effects, contraindications for use, and is it possible to overdose on them?
Peptide bioregulators have no side effects, apart from possible individual intolerance to the capsule components (gelatin shell or excipients). The absence of side effects is explained by the mechanism of action of peptide bioregulators. They do not start any chemical reactions in the cells that are not characteristic of this organism. All they do is adjust and activate natural physiological processes. Therefore, there are no adverse reactions. In fact, there are no contraindications to the use of peptide bioregulators either. However, we ask our partners to be more careful when recommending peptide bioregulators to people who are extremely weak, seriously ill, or in terminal conditions. In such cases, the issue of prescribing any therapy, including bioregulators, should be decided by the attending physician.
Here I will immediately highlight another feature of peptides - their regulatory effect. To normalize tissue and organ function, we use the same peptide bioregulator, regardless of whether tissue function is increased or decreased. For example, in hyperfunction of the thyroid gland, we use the same peptide bioregulator "Thyreogen" from the tissues of the thyroid gland. It normalizes the level of hormones, reducing or increasing their synthesis in the cell at the level of changes in gene expression, that is, at the level of reading information from DNA strands.
Therefore, it is clear that there can be no overdose on peptide bioregulators. As soon as all regulated DNA strands are occupied by complementary peptide ones, the remaining "out of work" bioregulators will simply be split by the cell into their original fragments - that is, into amino acids - and used for their intended purpose, for the synthesis of their proteins.
The dose only affects the speed of the onset of the effect; because the more complementary molecules enter the body at the same time, the higher their chance is to quickly reach the desired genes.
Is there a withdrawal syndrome when using peptide bioregulators, and how long will the effect of the bioregulator last?
With the use of peptide bioregulators, withdrawal syndrome does not occur. After all, our peptides are not artificially synthesized and introduced into the body from outside hormones, which, according to the principle of "negative feedback", suppress the synthesis of their own hormones. Peptide bioregulators are molecules that transmit a signal to cells about the synthesis of their own hormones in the amount necessary for the body. The hypothalamic-pituitary mechanism of endocrine self-regulation is not disturbed either.
The duration of the post-effect from the use of a peptide bioregulator depends on a number of factors. First of all, on the type of bioregulator. All synthesized peptide bioregulators (cytogenes, Revilab SL/ML series) have a faster but shorter duration of action. Usually the effect lasts for about one month, then the bioregulator needs to be reapplied. Peptide bioregulators based on natural peptides, cytomaxes, have a longer post-effect - about 2-3 months. That is why we recommend starting bioregulation with faster synthesized peptides and finishing it with cytomaxes.
Of course, the duration of the post-effect also largely depends on the age and initial state of your body. The older a person is and the more chronic diseases he has, the longer it will take to use bioregulators to normalize body functions. In this case, peptide bioregulators are used constantly, without interruption, only the type of bioregulator changes, that is, the point of application - adjustment.
If a person is young and healthy and plans to carry out bioregulation in a prophylactic regime, as a rule, one or two courses of peptide support per year are enough.
Since peptide bioregulators restore physiological processes in the cell, they are all compatible both with each other and with any other drugs. However, we do not recommend using more than six peptide bioregulators at the same time; it simply does not make sense. The body may not have enough resources to work in more than six directions at the same time. If the patient is using any other medications, we advise him to discuss the use of bioregulators with their attending physician or a medical consultant of our company.
Can the use of peptide bioregulators cause allergic reactions or autoimmune diseases?
No, it can not. Our peptide bioregulators have a molecular weight of less than 5 kD, such molecules are too small to trigger an immune response. Amino acids themselves are the natural building material of our body, and they cannot provoke an allergic reaction either.
However, some of our clients complain about allergic manifestations that occur one to two weeks after the start of the use of peptides. What is the reason? The reason may be that the body needs to detoxify.
Peptide bioregulators, when in the body, restore the natural functions of cells. One of these functions is the ability of the cell to purify, release from toxic substances that arise in it during life. Cells begin to actively "take out the trash" out into the intercellular space. And not only the one that they synthesized now, but also all those slags that they accumulated for many years, not being able to get rid of them.
The intercellular fluid is overflowing with toxins, and they all go to the lymph and blood, the liver and kidneys try to clear the fluids from the influx of toxins and cannot cope, the toxins begin to settle again in the tissues: skin, joints, and muscles. Hence the symptoms: headaches, weakness, skin rashes, pain in the joints and muscles, and much more. With continued use of bioregulators, the purification processes will be restored, and the symptoms of intoxication will go away.
That is why we recommend our clients to carry out a course of body cleansing and activation of intra- and extracellular detoxification processes before starting peptide bioregulation. It can be carried out according to the "Express Detoxification" plan, which is included in our methodological guide "Complex application." This will help you avoid such unpleasant manifestations at the start.
What will be the overall effect of taking bioregulators? What should I feel/expect?
If you are young and healthy, then you will remain so. The effect of bioregulatory therapy will manifest itself in the distant future, when, having lived to an advanced age, you will look much younger than your peers, maintain health, vigor and working capacity.
Unfortunately, very few people come to us at a young age and in a healthy state. Most already have a whole "bouquet" of diagnoses. Well, we will try to help you part with at least some of them. Restore the functions of organs, improve the quality of life, and maybe even regain your former health.
However, a lot depends on you. The sooner you take care of your health, the easier it will be for us to help you maintain it.
Be attentive to your health!
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